Shinsaku Imashuku Selected Research

Therapeutics

8/2018	Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study.
7/2016	Intensified and prolonged therapy comprising cytarabine, vincristine and prednisolone improves outcome in patients with multisystem Langerhans cell histiocytosis: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study.
2/2015	Follow-up of pediatric patients treated by IVIG for Langerhans cell histiocytosis (LCH)-related neurodegenerative CNS disease.
1/2015	Commentary: Intravenous Immunoglobulin (IVIG) Therapy for Patients with Langerhans Cell Histiocytosis (LCH)-Related Neurodegenerative Diseases of the CNS.
1/2013	Therapeutic outcome of multifocal Langerhans cell histiocytosis in adults treated with the Special C regimen formulated by the Japan LCH Study Group.
10/2011	Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.
5/2011	Chlamydia pneumoniae infection-related hemophagocytic lymphohistiocytosis and acute encephalitis and poliomyelitis-like flaccid paralysis.
4/2011	Thrombotic thrombocytopenic purpura in a child with systemic lupus erythematosus.
2/2008	Treatment of neurodegenerative CNS disease in Langerhans cell histiocytosis with a combination of intravenous immunoglobulin and chemotherapy.
2/2006	Control of hepatic veno-occlusive disease with an antithrombin-III concentrate-based therapy.

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Shinsaku Imashuku Research Topics

Disease

24	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 01/2021 - 08/2003
13	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 09/2013 - 02/2002
10	Neoplasms (Cancer) 10/2021 - 07/2004
9	Leukemia 12/2018 - 02/2002
8	Infections 01/2018 - 07/2004
7	Hemorrhage 03/2021 - 01/2012
7	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2018 - 02/2002
6	Lymphoma (Lymphomas) 01/2023 - 03/2003
6	Hemolytic Anemia 01/2022 - 09/2003
6	Central Nervous System Diseases (CNS Diseases) 10/2015 - 06/2002
6	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2004 - 06/2002
5	Anemia 04/2024 - 05/2005
3	Hemochromatosis (Bronze Diabetes) 04/2024 - 07/2016
3	Sepsis (Septicemia) 04/2021 - 07/2004
3	Thrombosis (Thrombus) 04/2021 - 01/2019
3	Fever (Fevers) 01/2016 - 03/2005
3	Autoimmune Diseases (Autoimmune Disease) 01/2015 - 01/2011
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 11/2009
3	Chromosome Aberrations (Chromosome Abnormalities) 11/2003 - 04/2003
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2023 - 01/2006
2	Hematologic Neoplasms (Hematological Malignancy) 01/2023 - 01/2004
2	Thromboembolism 01/2021 - 06/2020
2	Hyperhomocysteinemia 01/2021 - 06/2020
2	Juvenile Xanthogranuloma 01/2020 - 06/2004
2	Neurogenic Diabetes Insipidus (Central Diabetes Insipidus) 01/2019 - 12/2011
2	Juvenile Myelomonocytic Leukemia 12/2018 - 08/2004
2	Pathologic Complete Response 12/2018 - 06/2005
2	Hyperbilirubinemia 04/2018 - 01/2018
2	Diabetes Mellitus 02/2018 - 07/2016
2	Septic Shock (Toxic Shock Syndrome) 01/2018 - 04/2011
2	Hemolysis 01/2018 - 06/2016
2	Diabetes Insipidus 01/2018 - 11/2004
2	Pneumonia (Pneumonitis) 01/2017 - 09/2002
2	Hemophilia A (Haemophilia) 12/2015 - 01/2012
2	Thrombocytopenia (Thrombopenia) 10/2015 - 10/2005
2	Inflammation (Inflammations) 02/2015 - 01/2015
2	Hematologic Diseases (Blood Diseases) 01/2015 - 11/2007
2	Hearing Loss (Hearing Impairment) 11/2007 - 07/2004
2	Neutropenia 01/2006 - 11/2003
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 10/2005 - 08/2003
2	GATA2 Deficiency 06/2005 - 11/2003
2	Aplastic Anemia (Anemia, Hypoplastic) 06/2005 - 11/2003
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 05/2004 - 08/2003
1	Iron Overload 04/2024
1	Spinal Cord Diseases 01/2023
1	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 01/2023
1	Paraplegia (Spastic Paraplegia) 01/2023
1	Anaphylaxis (Anaphylactic Shock) 08/2022
1	Iron Deficiencies 01/2022

Drug/Important Bio-Agent (IBA)

8	Prednisolone (Predate)FDA LinkGeneric 01/2020 - 05/2005
7	Intravenous Immunoglobulins (IVIG)FDA Link 10/2021 - 10/2005
6	PerforinIBA 11/2007 - 01/2005
5	Rituximab (Mabthera)FDA Link 01/2023 - 05/2005
5	Etoposide (VP 16)FDA LinkGeneric 10/2021 - 02/2002
5	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2021 - 03/2005
4	CytokinesIBA 01/2017 - 01/2006
4	Proteins (Proteins, Gene)FDA Link 09/2009 - 02/2002
3	HomocysteineIBA 01/2021 - 04/2018
3	Interleukin-1 (Interleukin 1)IBA 01/2018 - 01/2015
3	Immunosuppressive Agents (Immunosuppressants)IBA 04/2011 - 11/2003
3	Protein Isoforms (Isoforms)IBA 05/2008 - 02/2002
3	Imatinib Mesylate (Gleevec)FDA Link 05/2005 - 08/2003
2	Methotrexate (Mexate)FDA LinkGeneric 01/2023 - 11/2003
2	Protein CIBA 04/2021 - 01/2020
2	recombinant FVIIa (rFVIIa)FDA Link 03/2021 - 01/2012
2	Mitogen-Activated Protein KinasesIBA 01/2021 - 10/2020
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021 - 06/2020
2	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 06/2020 - 04/2018
2	Factor V (Coagulation Factor V)IBA 10/2019 - 01/2011
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2019 - 07/2016
2	AntibodiesIBA 04/2018 - 01/2015
2	Intrinsic Factor FDA Link 04/2018 - 01/2015
2	ChemokinesIBA 01/2017 - 12/2014
2	Biomarkers (Surrogate Marker)IBA 10/2015 - 08/2006
2	Immunoglobulins (Immunoglobulin)IBA 10/2015 - 11/2009
2	Immunoglobulin G (IgG)IBA 01/2013 - 09/2009
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 06/2005 - 11/2003
2	Tacrolimus (Prograf)FDA LinkGeneric 03/2005 - 11/2003
2	EnzymesIBA 03/2005 - 09/2003
2	Melphalan (Alkeran)FDA LinkGeneric 11/2003 - 03/2003
1	MetalsIBA 04/2024
1	Familial apoceruloplasmin deficiencyIBA 04/2024
1	Transferrin (beta 2 Transferrin)IBA 04/2024
1	metal transporting protein 1 (ferroportin)IBA 04/2024
1	IronIBA 04/2024
1	Bendamustine Hydrochloride FDA Link 01/2023
1	cold agglutininsIBA 01/2023
1	AgglutininsIBA 01/2023
1	Epinephrine (Adrenaline)FDA LinkGeneric 08/2022
1	HemosiderinIBA 01/2022

Therapy/Procedure

18	Therapeutics 08/2018 - 02/2002
14	Drug Therapy (Chemotherapy) 01/2023 - 09/2003
8	Aftercare (After-Treatment) 01/2023 - 04/2003
8	Hematopoietic Stem Cell Transplantation 10/2021 - 06/2002
8	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/2005 - 09/2002
5	Transplantation 01/2020 - 09/2002
2	Renal Dialysis (Hemodialysis) 10/2019 - 01/2018
2	Tooth Extraction (Tooth Extractions) 01/2018 - 12/2015
2	Stem Cell Transplantation 01/2016 - 05/2004
2	Splenectomy 06/2012 - 12/2004